The word "不屑一顾" is formed by sequentially combining the characters "不" (not), "屑" (to consider worthwhile), "一" (one), and "顾" (to look), where "不屑" negates the value of something and "一顾" refers to a single glance, resulting in a literal meaning of "not deeming it worthy of a single glance" to express contempt or disregard.